SS-31 (Elamipretide)
A mitochondria-targeting peptide studied in cellular-energy research.
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Overview
SS-31 (elamipretide) is a peptide with an unusual talent: it localizes to the inner membrane of the mitochondria, where it binds a lipid called cardiolipin that's essential to how those energy factories work. That targeting is why it's studied so closely in research into mitochondrial function and cellular energy.
Maddox SS-31 is a high-purity, independently tested peptide delivered by injection. People interested in mitochondrial health and the cellular energy-and-stress response reach for it because of that mitochondria-first mechanism. Available evidence spans preclinical and early clinical work.
Targeted support, right at the powerhouse.
What draws people to SS-31, based on its studied mitochondria-targeting mechanism:
Mitochondrial function
Studied for how it localizes to the inner mitochondrial membrane where cellular energy is produced.
Cardiolipin interaction
Examined for its binding to cardiolipin, a lipid essential to healthy mitochondrial structure.
Energy & stress response
Investigated for its role in how cells manage energy demand and oxidative stress.
Independently tested
Every batch of SS-31 is third-party tested and ships with a certificate of analysis.
How it works
SS-31's defining feature is where it goes. It concentrates at the inner mitochondrial membrane and binds cardiolipin — a lipid that helps organize the machinery cells use to generate energy. Researchers study this interaction because healthy cardiolipin is tied to efficient, well-functioning mitochondria.
By targeting that membrane, SS-31 is examined in research for its effects on mitochondrial energy production and the cellular response to oxidative stress. The evidence spans both preclinical models and early clinical studies, so it's best understood as an active and evolving area. Maddox supplies SS-31 at a purity confirmed by independent testing.
How to use
- 1
Reconstitute
If supplied as a lyophilized powder, add bacteriostatic water per the included instructions and swirl gently until fully dissolved.
- 2
Dose
Dosing should be set with a healthcare provider based on your goals and health history — protocols are individualized and not something to self-direct.
- 3
Administer
Administration should be demonstrated and directed by a healthcare provider familiar with your protocol.
- 4
Store
Keep refrigerated after reconstitution and use within the window on your instructions. Keep out of reach of children.
Independently tested, every batch
Every lot is tested by an independent lab and ships with a certificate of analysis, so what's on the label is what's in the vial.
Safety & important considerations
- Talk with a qualified healthcare provider before starting, especially if you take medication or have a health condition.
- Evidence for SS-31 spans preclinical and early clinical work; approach it as an evolving research area.
- Not a substitute for professional medical care, diagnosis, or treatment.
- Stop and seek care if you experience any reaction that concerns you.
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Frequently asked questions
What makes SS-31 different?＋
It's studied for localizing directly to the inner mitochondrial membrane and binding cardiolipin — a targeted mechanism most peptides don't share.
Is SS-31 the same as elamipretide?＋
Yes. SS-31 and elamipretide are two names for the same peptide.
What's the state of the evidence?＋
It spans preclinical models and some early clinical work, so it's an active, evolving area rather than a settled one.
Is Maddox SS-31 tested?＋
Yes. Every batch is independently tested and ships with a certificate of analysis confirming identity and purity.
Can I combine it with other products?＋
Many people build stacks, but any combination should be reviewed with a knowledgeable provider first.
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